منابع مشابه
angiogenesis and tumor
angiogenesis, the process of new blood vessel formation from existing ones, plays an important role in the physiologic circumstances such as embryonic development, placenta formation, and wound healing. it is also crucial to progress of pathogenic processes of a variety of disorders, including tumor growth and metastasis. in general, angiogenesis process is a multi-factorial and highly structu...
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Introduction: Angiogenesis, the process of new blood vessel formation from pre-existing vessels, has important physiological roles in embryonic development, female reproduction cycle, and wound healing. It is also crucial for pathological processes in several diseases especially tumor growth and metastasis. Thereby, inhibition of angiogenesis as an addition to the conventional therapies such...
متن کاملTumor microenvironment and angiogenesis.
The tumor microenvironment is a mixture of extracellular matrix molecules, tumor cells, endothelial cells, fibroblasts and immune cells. Tumor growth and metastasis formation are dependent on the growth of blood vessels into the tumor mass. The tumor microenvironment contributes to this pathological angiogenic process. The extracellular matrix and basement membranes are a source for endogenous ...
متن کاملAngiogenesis and tumor metastasis.
Angiogenesis, the recruitment of new blood vessels, is an essential component of the metastatic pathway. These vessels provide the principal route by which tumor cells exit the primary tumor site and enter the circulation. For many tumors, the vascular density can provide a prognostic indicator of metastatic potential, with the highly vascular primary tumors having a higher incidence of metasta...
متن کاملVEGF and Tumor Angiogenesis
Based on successful preclinical data, over twenty antiangiogenic agents, alone or in combination with conventional therapies, are now in clinical trial. In the year 2000, close to 1,000 manuscripts describing the basic molecular and cellular mechanisms that allow for an angiogenic response have been published. The goal of this review is to summarize the reasons that angiogenesis re s e a rch ha...
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ژورنال
عنوان ژورنال: Japanese Journal of Thrombosis and Hemostasis
سال: 2010
ISSN: 1880-8808,0915-7441
DOI: 10.2491/jjsth.21.283